The question
Where does scale-up get difficult?
Bioreactor performance is one part of a larger system. Media, cleaning, cooling, sterilization, downstream processing, and waste all shape the facility.
The model
One connected flowsheet.
The literature-based model connects cell expansion, production, downstream processing, equipment, and utilities through mass and energy balances.
The use
Compare the whole system.
Explore manufacturing scenarios, inspect assumptions, compare utility demands, and identify priorities for further validation.
Literature-based research model. Pilot and industrial validation are pending.
← Selected work