Selected work Flagship case study · 2026
Industrial process model Bioengineering

Making an industrial process visible before it exists.

A transparent, plant-wide model for cultivated meat manufacturing—connecting media preparation, cell expansion, downstream processing, utilities, and uncertainty in one explorable system.

FACILITY MODEL / LIVE SCENARIO 01
01 Media prepare
02 Cells expand
03 20k L produce
04 DSP recover
MassEnergyTimeUtilities
20,000 LFinal stirred-tank reactor
≈2,000 kgModeled biomass per batch
30.7 daysModeled batch duration
04Explorable process scenarios
The throughline

Problem → model → insight → decision.

The value is not a single number. It is a system that makes assumptions inspectable, consequences comparable, and the next engineering question more precise.

01 / Problem

Scale-up evidence was fragmented.

Industrial translation depends on more than a bioreactor. Media, seed expansion, sterilization, downstream operations, cleaning, cooling, timing, and waste all interact—but are often studied separately.

The challenge: create one coherent facility view without hiding the gaps in available data.

02 / Model

One flowsheet. Every major process area.

The model links literature-grounded assumptions across media preparation, sequential suspension-cell expansion, a 20,000 L production reactor, clarification, washing, extrusion, packaging, and supporting utilities.

The result: complete mass and energy balances with scenarios that can be inspected and compared.

03 / Insight

The bottlenecks extend beyond cell growth.

Depleted medium, cleaning-in-place effluents, cooling demand, and the trade-off between heat sterilization and sterile filtration emerge as critical facility-level considerations.

The shift: from optimizing one unit operation to understanding the industrial system around it.

04 / Decision

Focus experiments and design work where they change the system.

The model creates a quantitative basis for comparing process configurations, identifying missing engineering data, and prioritizing validation before facility and scale-up commitments.

The decision tool: an open, interactive model rather than a static conclusion.

Inside the model

From cryostock to
packaged biomass.

Each step carries its inputs, outputs, timing, equations, equipment, utilities, and assumptions into the next.

  1. 01Prepare

    Blend medium components; compare sterile-filtration and heat-sterilization splits.

  2. 02Expand

    Move through shake flasks, wave bioreactors, and stirred-tank reactors.

  3. 03Produce

    Model suspension culture in the final 20,000 L stirred-tank reactor.

  4. 04Recover

    Clarify, wash, cool, extrude, fill, and account for product and waste streams.

  5. 05Interrogate

    Compare scenarios, inspect balances, and export the full technical data package.

Your process / Next

What would become clear
if your whole process were visible?

Bring me the process, the uncertainty, and the decision it needs to unlock.

Discuss your process challenge